Zobrazit minimální záznam

dc.contributor.authorHolešová, Sylva
dc.contributor.authorValášková, Marta
dc.contributor.authorHlaváč, Dominik
dc.contributor.authorMadejová, Jana
dc.contributor.authorSamlíková, Magda
dc.contributor.authorTokarský, Jonáš
dc.contributor.authorPazdziora, Erich
dc.date.accessioned2015-03-09T12:08:56Z
dc.date.available2015-03-09T12:08:56Z
dc.date.issued2014
dc.identifier.citationApplied Surface Science. 2014, vol. 305, p. 783-791.cs
dc.identifier.issn0169-4332
dc.identifier.issn1873-5584
dc.identifier.urihttp://hdl.handle.net/10084/106675
dc.description.abstractClay minerals are commonly used materials in pharmaceutical production both as inorganic carriers or active agents. The purpose of this study is the preparation and characterization of clay/antibacterial drug hybrids which can be further included in drug delivery systems for treatment oral infections. Novel nanocomposites with antibacterial properties were successfully prepared by ion exchange reaction from two types of kaolinite/urea intercalates and chlorhexidine diacetate. Intercalation compounds of kaolinite were prepared by reaction with solid urea in the absence of solvents (dry method) as well as with urea aqueous solution (wet method). The antibacterial activity of two prepared samples against Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was evaluated by finding the minimum inhibitory concentration (MIC). Antibacterial studies of both samples showed the lowest MIC values (0.01%, w/v) after 1 day against E. faecalis, E. coli and S. aureus. A slightly worse antibacterial activity was observed against P. aeruginosa (MIC 0.12%, w/v) after 1 day. Since samples showed very good antibacterial activity, especially after 1 day of action, this means that these samples can be used as long-acting antibacterial materials. Prepared samples were characterized by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The experimental data are supported by results of molecular modelling.cs
dc.language.isoencs
dc.publisherElseviercs
dc.relation.ispartofseriesApplied Surface Sciencecs
dc.relation.urihttp://dx.doi.org/10.1016/j.apsusc.2014.04.008cs
dc.rightsCopyright © 2014 Elsevier B.V. All rights reserved.cs
dc.titleAntibacterial kaolinite/urea/chlorhexidine nanocomposites: Experiment and molecular modellingcs
dc.typearticlecs
dc.identifier.doi10.1016/j.apsusc.2014.04.008
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume305cs
dc.description.lastpage791cs
dc.description.firstpage783cs
dc.identifier.wos000336525400109


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