|dc.identifier.citation||Virchows archiv. 2009, vol. 455, Suppl. 1, p. 401.||en
|dc.description.abstract||Background The 21st century opened with a revolution
due to nanotechnology as special emerging technology.
We have heard about nanobiotechnology, nanomedicine,
nanomaterials, nanoparticles, etc. Applications of nanotechnologies
in the field of medicine are growing rapidly.
Areas such as disease diagnosis, drug delivery and
molecular imaging are being investigated intensively.
The aim of the study was to identify nano-sized particles
in human tonsils tissues as an entering filter of air
Methods Three main groups of tonsil samples were
chosen for evaluation of the fine-particles presence. First
group of samples were randomly selected tonsils of
children undergoing “cold” tonsillectomy, second group
tonsil samples of dead born children, and third group were
tonsils with histologically proved spinocellular carcinoma.
Dehydrated tissue samples were analyzed using scanning
electron microscope with X-ray microanalysis (SEMEDX),
which enabled analysis of particles morphology
and elemental composition.
Results Presence of various nanostructured metallic
agglomerates in all groups assessed was confirmed.
Dominant metals found almost in all tissues analyzed
were iron and zinc. Differences were found between
groups of various age, lifestyle, living environment
affected by industrial processes and last but not least
Conclusion(s) The study allowed to ascertain that environmental
pollution may strongly affect human health.
Through SEM-EDX analysis it was possible to verify
character and composition of particles, unintentionally
released into the environment by industrial processes and
road traffic, which were present in pathological tissues.||en
|dc.title||Nanopathology: nano-sized particles in human tonsil tissues||en
|dc.identifier.location||Není ve fondu ÚK||en