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dc.contributor.authorHonegr, Jan
dc.contributor.authorSoukup, Ondřej
dc.contributor.authorDoležal, Rafael
dc.contributor.authorMaliňák, David
dc.contributor.authorPenhaker, Marek
dc.contributor.authorPrymula, Roman
dc.contributor.authorKuča, Kamil
dc.date.accessioned2015-11-03T07:39:34Z
dc.date.available2015-11-03T07:39:34Z
dc.date.issued2015
dc.identifier.citationCurrent Medicinal Chemistry. 2015, vol. 22, issue 29, p. 3306-3325.cs
dc.identifier.issn0929-8673
dc.identifier.issn1875-533X
dc.identifier.urihttp://hdl.handle.net/10084/110537
dc.descriptionPubMed ID: 26295466
dc.description.abstractToll like receptors (TLRs) are a family of transmembrane proteins which play a key role in innate immunity. When TLRs come into contact with a potential threat, they initiate a signaling cascade leading to release of cytokines and chemokines, maturation of antigen presenting cells and immune activation. Molecules which can activate TLRs may be utilized for vaccine development and act as vaccine adjuvants. Adjuvants can facilitate production of more effective vaccines based on antigens produced by recombinant techniques or by DNA vaccines, which are often poorly immunogenic since they lack the endogenous innate immunostimulatory components of the pathogen. In this paper the structural properties of such prospective compounds are thoroughly discussed. - See more at: http://www.eurekaselect.com/134203/article#sthash.A755yJzh.dpufcs
dc.language.isoencs
dc.publisherBentham Sciencecs
dc.relation.ispartofseriesCurrent Medicinal Chemistrycs
dc.relation.urihttp://dx.doi.org/10.2174/0929867322666150821094634cs
dc.subjectImmunologic adjuvantscs
dc.subjectTLRcs
dc.subjectvaccinescs
dc.subjectSMIPcs
dc.subjectinnate immunitycs
dc.subjectdrug designcs
dc.subjecttargetingcs
dc.subjectToll-like receptorcs
dc.titleStructural Properties of Potential Synthetic Vaccine Adjuvants - TLR Agonistscs
dc.typearticlecs
dc.identifier.doi10.2174/0929867322666150821094634
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume22cs
dc.description.issue29cs
dc.description.lastpage3325cs
dc.description.firstpage3306cs
dc.identifier.wos000362114900001


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