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Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects

dc.contributor.authorManukyan, Gayane
dc.contributor.authorPapajík, Tomáš
dc.contributor.authorGajdoš, Petr
dc.contributor.authorMikulková, Zuzana
dc.contributor.authorUrbanová, Renata
dc.contributor.authorGabčová, Gabriela
dc.contributor.authorKudělka, Miloš
dc.contributor.authorTurcsányi, Peter
dc.contributor.authorRyznerová, Pavlína
dc.contributor.authorProcházka, Vít
dc.contributor.authorKriegová, Eva
dc.date.accessioned2017-11-03T14:09:26Z
dc.date.available2017-11-03T14:09:26Z
dc.date.issued2017
dc.identifier.citationOncotarget. 2017, vol. 8, issue 49, p. 84889-84901.cs
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/10084/121155
dc.description.abstractA growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL). The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy controls. Neutrophils from CLL produced more reactive oxygen species (ROS) compared to controls in both resting and activated conditions. Lipopolysaccharide-induced production of IL-1 beta and TNF-a as well as reduced TLR2 expression in neutrophils from CLL than in neutrophils from controls suggesting their tolerant state. Finally, phenotypic alterations of neutrophils, particularly elevation of CD64 and CD54 markers, correlated with disease activity and treatment, and low percentage of neutrophils. Taken together, the alterations in percentage and functional characteristics of neutrophils reflect the clinical course of CLL. Our data provide first evidence that neutrophils in CLL are permanently primed and have functional defects.cs
dc.format.extent2215333 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoencs
dc.publisherImpact Journals, LLCcs
dc.relation.ispartofseriesOncotargetcs
dc.relation.urihttps://doi.org/10.18632/oncotarget.20031cs
dc.rightsCopyright: Manukyan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CCcs
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/cs
dc.subjectchronic lymphocytic leukemiacs
dc.subjectneutrophilscs
dc.subjectdisease activitycs
dc.subjectflow cytometrycs
dc.subjectenhanced ROS productioncs
dc.titleNeutrophils in chronic lymphocytic leukemia are permanently activated and have functional defectscs
dc.typearticlecs
dc.identifier.doi10.18632/oncotarget.20031
dc.rights.accessopenAccess
dc.type.versionpublishedVersioncs
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume8cs
dc.description.issue49cs
dc.description.lastpage84901cs
dc.description.firstpage84889cs
dc.identifier.wos000413077800036


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Copyright: Manukyan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC
Except where otherwise noted, this item's license is described as Copyright: Manukyan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC