| dc.contributor.author | Vaculíková, Eliška | |
| dc.contributor.author | Pokorná, Aneta | |
| dc.contributor.author | Plachá, Daniela | |
| dc.contributor.author | Pisárčik, Martin | |
| dc.contributor.author | Dědková, Kateřina | |
| dc.contributor.author | Peikertová, Pavlína | |
| dc.contributor.author | Devínsky, Ferdinand | |
| dc.contributor.author | Jampílek, Josef | |
| dc.date.accessioned | 2019-04-03T11:53:20Z | |
| dc.date.available | 2019-04-03T11:53:20Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | Journal of Nanoscience and Nanotechnology. 2019, vol. 19, issue 5, p. 3031-3034. | cs |
| dc.identifier.issn | 1533-4880 | |
| dc.identifier.issn | 1533-4899 | |
| dc.identifier.uri | http://hdl.handle.net/10084/134468 | |
| dc.description.abstract | Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 mu g/ml) compared with bulk (0.024 mu g/ml). | cs |
| dc.language.iso | en | cs |
| dc.publisher | American Scientific Publishers | cs |
| dc.relation.ispartofseries | Journal of Nanoscience and Nanotechnology | cs |
| dc.relation.uri | http://doi.org/10.1166/jnn.2019.15876 | cs |
| dc.subject | glibenclamide | cs |
| dc.subject | nanoparticles | cs |
| dc.subject | solubility | cs |
| dc.subject | carboxymethyl dextran sodium salt | cs |
| dc.subject | dynamic light scattering | cs |
| dc.subject | infrared spectroscopy | cs |
| dc.subject | scanning electron microscopy | cs |
| dc.title | Improvement of glibenclamide water solubility by nanoparticle preparation | cs |
| dc.type | article | cs |
| dc.identifier.doi | 10.1166/jnn.2019.15876 | |
| dc.type.status | Peer-reviewed | cs |
| dc.description.source | Web of Science | cs |
| dc.description.volume | 19 | cs |
| dc.description.issue | 5 | cs |
| dc.description.lastpage | 3034 | cs |
| dc.description.firstpage | 3031 | cs |
| dc.identifier.wos | 000458402700079 | |