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dc.contributor.authorSosna, Tomáš
dc.contributor.authorMikeska, Marcel
dc.contributor.authorDutko, Ondřej
dc.contributor.authorSimha Martynková, Gražyna
dc.contributor.authorŠkrlová, Kateřina
dc.contributor.authorČech Barabaszová, Karla
dc.contributor.authorDědková, Kateřina
dc.contributor.authorPeikertová, Pavlína
dc.contributor.authorPlachá, Daniela
dc.date.accessioned2019-04-04T08:51:41Z
dc.date.available2019-04-04T08:51:41Z
dc.date.issued2019
dc.identifier.citationJournal of Nanoscience and Nanotechnology. 2019, vol. 19, issue 5, p. 2814-2820.cs
dc.identifier.issn1533-4880
dc.identifier.issn1533-4899
dc.identifier.urihttp://hdl.handle.net/10084/134485
dc.description.abstractMost of drugs are only slightly soluble in the circulatory system of the human body. This reduces the efficiency of their use and that is why new ways how to increase their solubility are investigated. One way to improve the solubility of the drug is to reduce its particle size. Conventional techniques such as crushing or grinding usually do not guarantee a narrow particle size distribution, which is required for pharmaceuticals. Application of supercritical fluids, especially of supercritical CO2, seems to be convenient method for the preparation of pharmaceuticals submicron particles or nanoparticles. The method enables the preparation of particles in a narrow size distribution and at the same time it does not leave any unwanted residues of solvents or other chemicals. The aim of this work is the micronization of ibuprofen particles using the supercritical fluid and characterization of formed products. The micronization of the particles was done using commercially available device Spe-ed SFE-4 in rapid expansion of supercritical solution mode. The applied temperatures and pressures were 308.15 K and 313.15 K and 200, 250 and 300 bar. The prepared particles were characterized using methods of X-ray diffraction, infrared spectroscopy, particle size distribution, scanning electron microscopy and tests of dissolution and permeability. Mean particles size was reduced from 180 mu m (original ibuprofen) to 2.8-7.3 mu m of the processed samples. The dissolution test confirmed better solubility and the permeability of newly formed particles improved.cs
dc.language.isoencs
dc.publisherAmerican Scientific Publisherscs
dc.relation.ispartofseriesJournal of Nanoscience and Nanotechnologycs
dc.relation.urihttp://doi.org/10.1166/jnn.2019.15874cs
dc.subjectsupercritical fluidcs
dc.subjectparticle size distributioncs
dc.subjectibuprofencs
dc.subjectmicronizationcs
dc.subjectsupercritical CO2cs
dc.subjectpermeability testcs
dc.subjectdissolution testcs
dc.titleMicronization of ibuprofen particles using supercritical fluid technologycs
dc.typearticlecs
dc.identifier.doi10.1166/jnn.2019.15874
dc.type.statusPeer-reviewedcs
dc.description.sourceWeb of Sciencecs
dc.description.volume19cs
dc.description.issue5cs
dc.description.lastpage2820cs
dc.description.firstpage2814cs
dc.identifier.wos000458402700047


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