Mikronizace částic glibenclamidu s využitím superktitického CO2
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Vysoká škola báňská - Technická univerzita Ostrava
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The bachelor thesis is focused on the micronization of glibenclamide particles, a drug used for the treatment of diabetes II. type. The theoretical part was devoted to micronization of drugs, properties of glibenclamide and conditions leading to the formation of particles with the lowest possible size within the used method.In the practical part glibenclamide particles were micronised by supercritical fluid technology. Optimization of the conditions of the used technology was carried out, the resulting particles was characterized by the XRD, FTIR, PSD, SEM methods and the solubility of the generated particles was tested.
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glibenclamide, particle, micronization, supercritical fluid technology, supercritical carbon dioxide, CO2