Biodegradace léčiv s antipyretickým účinkem s využitím mikroorganismů

Abstract

The growing consumption of pharmaceutical compounds in recent years couse that anthropogenic pollution of aquatic ecosystems has been constantly increasing and pharmaceutical residues form a new significant type of toxic micropollutants in the environment. Acetaminophen is one of the most preferred and available substance from the group of antipyretics which becomes a very common waste drug due to the increased prescription of analgesics in medical practice. Physico-chemical waste water treatment systems are not fully effective in removing these micropollutant and becouse of that fact there are still new studies considering how to supplement these processes with biodegradation techniques, which are more effective in many cases and therefore significantly complement original methods. Master thesis is focused on the biotechnological removal of acetaminophen by using selected species of bacteria, microscopic fungi and yeast. The results of experimental work showed that the biodegradation of acetaminophen by using microscopic fungus Aspergillus clavatus was the most effective degradation. During 30 days of static cultivation almost 100 % of its initial concentration was degraded.