Tenké polymerní filmy s antimikrobiálním nanoplnivem

Abstract

This bachelor thesis deals with the preparation and characterization of thin polymer films with antimicrobial nanofiller, where the active organic antimicrobial component is antifungal ciclopiroxolamine. For possible synergistic effects, sample in combination with inorganic antimicrobial active ingredient zinc oxide was also prepared. The biodegradable polymer polycaprolactone was used as the polymer matrix and the carrier of antimicrobial components was the natural clay mineral vermiculite. The structure of the prepared samples was characterized by X-ray diffraction (X-ray) analysis, infrared spectroscopy (IR) and scanning electron microscopy (SEM). Furthermore, the organic carbon content was determined for powder samples and the particle size distribution (PSD) and -potential were also measured. The antimicrobial activity of both powder nanofillers and the resulting polymer films was tested against bacterial strains of Staphylococcus aureus and Escherichia coli and against the yeast Candida albicans. The tested materials seem to be active mainly in longer time intervals.