Příprava nanočástic léčiv s využitím superkritické tekutiny

Abstract

The bachelor thesis is focused on preparation of drugs nanoparticles, especially using supercritical fluids (SCFs). The aim of this thesis is preparation of nanoparticles of caffeine, aspirin, nifeldipine and cimetidine using supercritical fluids. For preparation was used an Applied Separations Spe-ed SFE-4 device. As a preparation method was used rapid expansion of supercritical solution (RESS). It was found that using this procedure, nanoparticles of caffeine and particles of aspirin can be prepared. No signs of nifedipine and cimetidine nanoparticles formation were observed. Also was discovered that with rising temperature, the size of caffeine and aspirin nanoparticles is decreasing, thus, it is possible to affect the size of nanoparticles by controlling the temperature. The Spe-ed SFE-4 is capable of preparation of drugs nanoparticles using RESS method.