Neparametrické a semi-parametrické modely v analýze přežití

Abstract

The aim of the diploma thesis is to describe non-parametric and semi-parametric methods of survival analysis and to test them on the real data. To achieve this, there are presented non-parametric models including Kaplan-Meier model, Log-rank test and life-table method, and semi-parametric Cox model. Furthermore the thesis focuses on regression diagnostic tools, especially residual analysis, a goodness of fit of model and its verification. Eventually, the presented theory is applied to real oncological data.