Antimikrobiální nanokompozitní filmy na bázi polykaprolaktonu a hybridních nanoplniv

Abstract

The bachelor thesis deals with the preparation and characterization of antimicrobial nanocomposite films based on polycaprolactone and hybrid nanofillers. Chlorhexidine diacetate and octenidine dihydrochloride were used as active organic components. Due to possible synergistic effects, nanofillers were prepared in combination with the inorganic component zinc oxide. The polymer matrix consisted of a highly biodegradable polymer polycaprolactone and the clay mineral vermiculite was used as a carrier for antimicrobial components. The prepared samples were characterized by X-ray diffraction analysis (XRD), infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and particle size distribution (PSD) and ζ-potential measurements were performed on powder samples. The wettability angle (WCA) of the polymer films was further measured, thermal analysis (TGA) was performed, and differential scanning calorimetry (DSC) was performed to determine the crystallinity of the polymer films. The antimicrobial efficacy of polymer films was tested against Staphylococcus aureus and Escherichia coli strains. The tested polymer films appear to be highly active, especially at shorter testing intervals.