Biodegradace biomateriálů ze směsí PLA/PHB v podmínkách in-vitro

Abstract

The thesis deals with the issue of biodegradation of biomaterials in conditions in-vitro. Biomaterials are systemically and pharmacologically inert substances intended for implantation or integration into the living system. The thesis describes various types of biomaterials that can be used as implants and the possibility of using 3D bioprint as a future method to accelerate their production and thus shorten the waiting time for patients. In the experimental part, the ability of blends based on polylactic acid and polyhydroxybutyrate with the addition of plasticizer triacetin is tested for biodegradation in simulated conditions of the human body, i.e. solutions with pH 4.5 – 7.2 at 37 °C. Experiments were performed using accelerated and natural biodegradation. Based on these results, it was confirmed that the biomaterial was biodegradable under these conditions.