Využití laserové dopplerometrie v mikrovaskulární diagnostice

Abstract

Laser Doppler Perfusion Imaging (LDPI) is a diagnostic method based on the Doppler shift of laser radiation reflected from moving blood cells. It provides quantitative maps of blood perfusion in the areas under investigation. Success of the treatment is correlated both with the perfusion values and their time evolution in the early post-injury period. The Burn Center of the University Hospital Ostrava gathers perfusion records of patients with differently serious burn injuries and variable treatment response since January 2010. The theoretical part of this Master Thesis is conceived as a basic material to introduce the principles of lasers to the students of Biomedical engineering, as well as an outline of the potential use of LDI in other biomedical applications. The practical part deals with image analysis of archived perfusion data which would enable ranking the patients into therapeutic categories based on the blood perfusion dynamics.