Životnost dialyzačního filtru z hlediska vývoje transmembranozního tlaku

Abstract

This thesis focuses on the method of continuous renal replacement therapy (CRRT), specifically on the measurement of pressures across the dialysis membrane (filter). Pressures within the extracorporeal circuit are continuously monitored throughout the entire treatment period. The lifespan of the dialysis set primarily depends on the filter’s permeability, which can be indirectly assessed based on filter pressure measurements. Excessively high or progressively increasing pressures indicate clot formation within the filter, leading to premature termination of the therapy and the need for circuit replacement. This is an undesirable situation that can endanger the patient (due to blood loss and insufficient dialysis dose) and also increases financial costs. The aim of this thesis is to analyze the development of membrane pressure values in relation to the filter’s lifespan, with the goal of identifying opportunities to prolong the filter’s effective use—ideally extending it to its intended full lifespan—through timely adjustments of therapy settings.