Improvement of glibenclamide water solubility by nanoparticle preparation

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dc.contributor.authorVaculíková, Eliška
dc.contributor.authorPokorná, Aneta
dc.contributor.authorPlachá, Daniela
dc.contributor.authorPisárčik, Martin
dc.contributor.authorDědková, Kateřina
dc.contributor.authorPeikertová, Pavlína
dc.contributor.authorDevínsky, Ferdinand
dc.contributor.authorJampílek, Josef
dc.date.accessioned2019-04-03T11:53:20Z
dc.date.available2019-04-03T11:53:20Z
dc.date.issued2019
dc.description.abstractGlibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 mu g/ml) compared with bulk (0.024 mu g/ml).cs
dc.description.firstpage3031cs
dc.description.issue5cs
dc.description.lastpage3034cs
dc.description.sourceWeb of Sciencecs
dc.description.volume19cs
dc.identifier.citationJournal of Nanoscience and Nanotechnology. 2019, vol. 19, issue 5, p. 3031-3034.cs
dc.identifier.doi10.1166/jnn.2019.15876
dc.identifier.issn1533-4880
dc.identifier.issn1533-4899
dc.identifier.urihttp://hdl.handle.net/10084/134468
dc.identifier.wos000458402700079
dc.language.isoencs
dc.publisherAmerican Scientific Publisherscs
dc.relation.ispartofseriesJournal of Nanoscience and Nanotechnologycs
dc.relation.urihttp://doi.org/10.1166/jnn.2019.15876cs
dc.subjectglibenclamidecs
dc.subjectnanoparticlescs
dc.subjectsolubilitycs
dc.subjectcarboxymethyl dextran sodium saltcs
dc.subjectdynamic light scatteringcs
dc.subjectinfrared spectroscopycs
dc.subjectscanning electron microscopycs
dc.titleImprovement of glibenclamide water solubility by nanoparticle preparationcs
dc.typearticlecs
dc.type.statusPeer-reviewedcs

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